The science
Instructions, delivered in order.
01 — The premise
Start with what's actually broken.
Chronic disease isn't just one thing gone wrong, human data tells a messier story. In complex conditions, multiple cell populations are failing at once, in relation to each other.
One cell type stops doing its job, the cells downstream never get the cue they were waiting for, and the whole coordinated process stalls.
02 — Why mRNA
The right tool for a dynamic problem.
mRNA is a set of temporary instructions. Deliver it, the cell makes what you asked for, and the instruction degrades.
For our purposes the useful part is control. You can decide what a cell produces, roughly how long it produces it, and what comes next. You can encode several functions in one design instead of choosing between them. And you can dose again when the biological context has progressed.
The technology is proven. mRNA products are approved, in clinical use, and moving through pipelines well beyond vaccines. We are developing the platform that uses that control to drive a staged, multi-mechanism recovery of cell function.
01 Instruct
02 Expire
03 Move to the next phase
03 — The solution
Our platform
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01
Targets chosen from human biology
We start with human single-cell transcriptomic data and look for what's functionally impaired in disease. That analysis defines the panel of candidates we take into the lab.
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02
Designed as a sequence
Candidates are designed to deliver phase-appropriate function: support the stage the cell is stuck in, then support the transition out of it. Timing is part of the design.
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03
Validated in relevant disease models
Candidates are validated in models that represent the disease state and we measure multiple outputs to fully characterise the mechanism of rescue.
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